6/28/2023 0 Comments Shahrzad series 2017 no 7![]() ![]() In the 1H NMR spectra there were singlets of H-3 (7.63 – 7.88 ppm) and H-8 (7.87 – 8.26 ppm) protons, as well as broad singlets of the NH2 group in the range of 7.05 – 7.21 ppm. The structure of the compounds synthesized was proven by spectral measurements. ![]() The reaction of N-Boc-4-aminopyrazole-5-carbaldehydes with creatinine in the presence of pyrrolidine as a catalyst in refluxing acetic acid allowed to obtain 6-aminoimidazopirazolopyridines with the yields of 54 – 70 %. This method was implemented through the stage of the intermediate aminoisocyanates formation.Experimental part. For the synthesis of their 6-oxoanalogs, the reaction of 5-aminopyrazolopyridine-6-carboxylic acids used in a modifed Curtius rearrangement with diphenylphosphorylazide was successful. It has been found that cyclocondensation of N-Boc-4-aminopyrazole-5-carbaldehydes with creatinine can be used as an effective method for obtaining 6-aminoimidazopyrazolopyridines previously unknown. To develop convenient approaches to the synthesis of 6-amino- and 6-oxoimidazopyrazolopyridines as promising biologically active scaffolds.Results and discussion.
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